The Science Behind OMPTM

Efficiently designing high-throughput, accurate diagnostics requires the ability to predict in advance precisely how oligonucleotides behave under the conditions of a given assay. To address this challenge, DNA Software has developed the Oligonucleotide Modeling PlatformTM (OMPTM), the computational environment which forms the foundation of the company's product line. With OMP, it is possible to predict the melting temperature (Tm) of a duplex within 2ºC, on average - significantly more accurately than other popular commercial software packages including Vector NTI 7.0 and Oligo 6.7. Those solutions simply lack the rigor and precision needed for today's demanding, high-throughput assays. DNA Software's chief scientist, Dr. John SantaLucia, has spent over 10 years developing a nearly complete database of thermodynamic parameters derived from hundreds of empirical observations. He also developed a better model for calculating thermodynamics that produces more accurate results.

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