DNA Software employs leading experts in the thermodynamics and hybridization
of nucleic acids and provides laboratory and consulting services to
major biotech companies working on development of nucleic acid based
assays and therapies, with one major feature being DNA
and RNA melting curve analyses.
Assay development:
- Effect of probe modification such as fluorophore incorporation
or nucleoside modifications on probe hybridization stability.
- Effect of probe modification on probe specificity and SNP discrimination
efficiency.
- Effect of buffer conditions and additives on hybridization stability.
- Consulting on assay design strategy and experimental testing
Custom Software and Probe design:
- Determination of nearest neighbor thermodynamic parameters for
hybridization prediction of proprietary chemistry oligonucleotides.
Formulation and Manufacturing
- Formulation of oligonucleotide therapeutics based on the effect
of buffer condition and annealing protocol on duplex/hairpin stability.
- Large volume oligonucleotide production consistency.
Regulatory Submissions
- Characterization of duplex/hairpin thermodynamics: melting temperature,
dG, dH, and dS, and secondary structure.
To inquire about our laboratory and consulting services please contact:
DNA Software, Inc.
204 East Washington Street
Ann Arbor, MI 48104
Office: +1 (734) 222-9080
Toll-Free: +1 (877) 362-7638
Fax: +1 (734) 222-9087
Email: info@dna-software.com
